Novak Djokovic lost his opening match at the 2026 U.S. Open to Mariano Navone on August 30 in New York by a score of 7-6(5), 5-7, 4-6, 6-2, 6-1 [Associated Press]. This result represents his earliest Grand Slam exit since the 2006 Australian Open and his first first-round defeat at the U.S. Open [Associated Press]. Djokovic holds the record of 24 men's Grand Slam singles titles, with his most recent coming at the 2023 U.S. Open [Associated Press].