An Ebola outbreak centered in Ituri province has spread to North Kivu, South Kivu, and Uganda, involving the Bundibugyo variant with 671 suspected cases and 160 suspected deaths reported. The WHO declared a public health emergency of international concern on 17 May amid challenges including an arson attack on a treatment center in Rwampara. Limited approved countermeasures exist for this variant, and transmission has occurred over several weeks in a region with ongoing displacement.